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Platelet-Rich Plasma
Platelet-Rich Plasma (PRP) is defined as an autologous concentrated preparation of platelets and their associated growth factors in a small volume of plasma. Platelets are a natural source of numerous growth factors in their natural and biologically-determined ratios. Plasma is the liquid aspect of our blood which contain all the cellular components such as red and white blood cells, as well as platelets.
In simple terms, platelets naturally make up only 10% of our blood's cellular components. In PRP, the platelet ratio is increased to 90% platelets. PRP injections offer an innovative and promising approach to tissue regeneration and healing in general.
Large quantities of activated platelets release growth factors that are stored in their granules, and which are part of the natural healing process. This leads to an induced inflammatory reaction that initiates a powerful effective healing cascade at the site of injury. Growth factors stimulate blood flow, promote matrix formation, restore proteins found in soft tissues that may have been previously compromised, and strengthens cartilage to become more firm and resilient.
These growth factors are signaling molecules that promote regeneration. Signaling molecules include Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor (TGF), Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), and Fibroblast Growth Factor (FGF).
These activated platelets also release other molecules that initiate and regulate the healing cascade of inflammation, cell proliferation, reepithelialization, angiogenesis and tissue remodeling.
Patients typically tolerate the procedure very well. One can expect a minor amount of post-injection soreness as PRP induces an inflammatory response.
One to three treatments are needed depending on the degree of injury, the duration of the injury and the response to the treatment.
PRP is the simplest and most affordable natural biologic injection option offered at Phenicell Regenerative Institute in Columbus, Ohio.
Common conditions treated by Platelet-Rich Plasma Therapy include:
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